Bradley Cooper has scrapped plans to romance Reese Witherspoon on the big screen – he’s dropped out of spy comedy This Means War to focus on The Hangover sequel.

The actor was due to team up with Witherspoon for the new movie, which sees two undercover agents fall in love with the same woman.

Terminator Salvation director McG is reportedly in negotiations to take charge of the picture, while production is slated to begin in July.

But Witherspoon will now be looking for a new leading man after Cooper pulled out of the project citing scheduling conflicts, according to EW.com.

Bosses at the website report Cooper will instead spend his time working on a follow-up to his successful Las Vegas comedy The Hangover, which is slated to begin filming later this year (10).

Katherine Heigl is set to star in bounty hunter movie One For The Money.

Variety reports Reese Witherspoon was originally due to take the lead role of unemployed lingerie buyer Stephanie Plum, but the project has been on hold for years and now the Ugly Truth star is attached to the movie.

The film is based on Janet Evanovich’s novel of the same name.

Tom Rosenberg, Gary Lucchesi and Wendy Finerman will produce the movie.

As well as her role on Grey’s Anatomy, Katherine has parts in forthcoming movies Killers and Life As We Know It.

Two of the biggest stars right now have been tapped to star alongside one another in the upcoming movie This Means War.

Reese Witherspoon is about to make every woman in the world jealous of her, since she’s snagged the leading role opposite Bradley Cooper.

The film is about two best friends since childhood who fall for the same woman (Witherspoon). Their friendship ends and their fight grows to epic proportions, taking out an entire city.

So not only does she get to act with Bradley, but she gets him to fight over her! Lucky girl! Charlie’s Angels director McG is helming this project.

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It seems like RPattz has a thing for blondes, because according Variety he might be teaming up with Reese Witherspoon on screen sometime in the near future.

Reese has already signed to star in the upcoming adaptation, “Water for Elephants.” Francis Lawrence, who directed “Constantine” and “I Am Legend,” is set to direct the film about a Cornell University veterinary student who joins the Benzini Brothers Most Spectacular Show on Earth to work as a veterinarian during the Great Depression.

Both Rob and Sean Penn are looking to join the screenplay, and we think it’s a smart choice for Rob to make. He is stretching his acting muscles with the upcoming “Remember Me” and “Bel Ami,” and “Water for Elephants” is just another step in the right direction. This is some serious acting, and getting a chance to work alongside greats like Sean and Reese will be good experience as well.

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Universal and Reese Witherspoon are going into the pharmaceutical business.

The studio is developing Pharm Girl, an aspirational comedy centering on one woman’s odyssey through the drug industry.

Bad Santa scribes Glenn Ficarra and John Requa are writing the screenplay and in talks to direct. Witherspoon is producing via her Type A banner and attached to the lead role.

The project centers on a woman (Witherspoon) who gets a job at a pharma powerhouse but begins to see the underbelly of the industry as she rises through the company’s ranks. Tracy Falco and Maradith Frenkel are overseeing for the studio.

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Jack Nicholson may reunite with James L. Brooks, the filmmaker who directed Nicholson to Oscar-winning performances in Terms of Endearment and As Good as It Gets.

Nicholson is in talks to join the cast of Brooks’ latest project, an untitled romantic comedy that stars Reese Witherspoon, Paul Rudd and Owen Wilson.

Written by Brooks, the story sees Witherspoon as a professional softball player torn between two men, a solid guy played by Rudd and a charming ball player with a 94-mile an hour fastball played by Wilson.

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